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Hypotheticals Return - not actual results!   Base Value: $1,251,709,648 Current Value: $1,397,980,168 Change: $146,270,520 Performance: 11.68 %

Name: Baker Bros Advisors Llc Last Trade: 2010-02-16 Owner Class: Institution Address: 667 Madison Avenue,17th Floor,New York Ny 10021, Phone: 2125212418 Fax: Website:

Stock Trading Hypotheticals

Hypotheticals use the owners holdings and changes reported as a model portfolio combining with stock price changes between the base price date and end price date. All results/returns are hypothetical and are not actual results!

Worst Move:	Lost $-272,935 on changes made with Cadence Pharmaceuticals Inc (CADX) buying shares when price went down.
Best Move:	Made $864,500 on changes made with Salix Pharmaceuticals Ltd (SLXP) buying shares when price went up.
Best Save:	Saved $-35,111,123 on changes made with Intermune Inc (ITMN) selling shares when price went down.
Missed Move:	Missed $3,968,322 on changes made with Xenoport Inc (XNPT) selling shares when price went up.

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Baker Bros Advisors Llc Stock Trading

Show ALL transactions instead of just the most recent 10:
Use 'As-Of/On' instead of 'Filed' for dates:		Begin date:		End date:
A begin price of 1900-01-01 will use the date filed for begin price:		Begin Price date:		End Price date:
- report date span limited to 100 days, all dates in format of yyyy-mm-dd, all fields required!

Transactions: Currently showing holdings/transactions Filed between 2009-11-18 and 2010-02-16

Prices: Currenty using base stock prices on Filing Date compared to stock prices on 2010-03-18

Show/Hide Columns Of Stock Trading Details

Filed	As-Of/On	Form	FullName
Symbol	Country	Industry	Shares
Activity	Shares Change	Shares Change Pct.	Hypothetical Old Value
Hypothetical New Value	Hypothetical Value Change	Hypothetical Return	Hypothetical Results
Director	Ten Pct	Other	Officer
Officer Title	History

Stock Trading: Ten Trades Most Recently Reported

Filed	As-Of/On	Form	Fullname	Symbol	Country	Industry	Shares	Activity	Shares Change	Shares Pct. Change	Hypothetical Old Value	Hypothetical New Value	Hypothetical Value Chg.	Hypothetical Return	Hypothetical Results	Director	Other	Ten Pct	Officer	Officer Title	History
2010-02-16	2009-12-31	13F-HR	Ap Pharma Inc	APPA	US	Drug Delivery Systems	6,861,818	Added More	3,977,272	137.88 %	-	-	-	- %							History of Baker Bros Advisors Llc Ownership Of Ap Pharma Inc
2010-02-16	2009-12-31	13F-HR	Threshold Pharmaceuticals Inc	THLD	US	Therapeutics	3,075,391	Added More	1,570,680	104.38 %	-	-	-	- %							History of Baker Bros Advisors Llc Ownership Of Threshold Pharmaceuticals Inc
2010-02-16	2009-12-31	13F-HR	Intermune Inc	ITMN	US	Medical-Biomedical/Gene	0	Sold All	-1,472,782	-100 %	-	-	-	152.33 %	$-35,111,123						History of Baker Bros Advisors Llc Ownership Of Intermune Inc
2010-02-16	2009-12-31	13F-HR	Inhibitex Inc	INHX	US	Medical-Biomedical/Gene	1,402,153	Added More	781,249	125.82 %	-	-	-	- %							History of Baker Bros Advisors Llc Ownership Of Inhibitex Inc
2010-02-16	2009-12-31	13F-HR	Allos Therapeutics Inc	ALTH	US	Therapeutics	5,064,909	Sold Some	-767,093	-13.15 %	$37,986,818	$39,455,641	$1,468,824	3.86 %	$-222,457						History of Baker Bros Advisors Llc Ownership Of Allos Therapeutics Inc
2010-02-16	2009-12-31	13F-HR	Ziopharm Oncology Inc	ZIOP	US	Medical-Biomedical/Gene	645,000	New Holding	645,000	100 %	-	-	-	- %							History of Baker Bros Advisors Llc Ownership Of Ziopharm Oncology Inc
2010-02-16	2009-12-31	13F-HR	Pharmathene Inc	PIP	US	Medical-Biomedical/Gene	323,807	Sold Some	-514,368	-61.36 %	$628,186	$560,186	$-67,999	-10.82 %	$108,017						History of Baker Bros Advisors Llc Ownership Of Pharmathene Inc
2010-02-16	2009-12-31	13F-HR	Chelsea Therapeutics International Inc	CHTP	US	Medical-Drugs	896,176	Sold Some	-465,087	-34.16 %	-	-	-	- %							History of Baker Bros Advisors Llc Ownership Of Chelsea Therapeutics International Inc
2010-02-16	2009-12-31	13F-HR	Cadence Pharmaceuticals Inc	CADX	US	Medical-Drugs	1,076,432	Added More	440,217	69.19 %	$10,290,690	$9,623,302	$-667,388	-6.48 %	$-272,935						History of Baker Bros Advisors Llc Ownership Of Cadence Pharmaceuticals Inc
2010-02-16	2009-12-31	13F-HR	Xenoport Inc	XNPT	US	Medical-Drugs	0	Sold All	-403,695	-100 %	-	-	-	-52.03 %	$3,968,322						History of Baker Bros Advisors Llc Ownership Of Xenoport Inc

Returned 10 Records!

Stock Trading Sources
Form Type	Filed	As-Of/On	Sec Filename
13F-HR	2010-02-16	2009-12-31	edgar/data/1263508/0001144204-10-008170.txt

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Note: All amounts are based on price of stock at date reported versus the current price! They do not represent actual profit/loss! There has been no adjustmentsfor splits!

Note: All amounts in USD, converted using Intrabank Exchange Rate on Date Reported/Today

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