| Filed | As-Of/On | Form | Fullname | Symbol | Country | Industry | Shares | Activity | Shares Change | Shares Pct. Change | Hypothetical Old Value | Hypothetical New Value | Hypothetical Value Chg. | Hypothetical Return | Hypothetical Results |
Director |
Other |
Ten Pct |
Officer |
Officer Title |
History |
|---|
| 2009-11-06 | 2009-09-30 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 48,088 | Sold Some | -72,826 | -60.22 % | $647,264 | $540,028 | $-107,236 | -16.56 % | $162,402 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2009-08-03 | 2009-06-30 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 120,914 | Added More | 69,614 | 135.69 % | $2,230,863 | $1,357,864 | $-872,999 | -39.13 % | $-502,613 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2009-05-04 | 2009-03-31 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 51,300 | Sold Some | -116,477 | -69.42 % | $806,436 | $576,099 | $-230,337 | -28.56 % | $522,982 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2009-02-13 | 2008-12-31 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 167,777 | Sold Some | -69,656 | -29.33 % | $2,457,933 | $1,884,136 | $-573,797 | -23.34 % | $238,224 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2008-11-06 | 2008-09-30 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 237,433 | Added More | 73,433 | 44.77 % | $3,433,281 | $2,666,373 | $-766,909 | -22.33 % | $-237,189 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2008-08-14 | 2008-06-30 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 164,000 | Added More | 33,100 | 25.28 % | $3,116,000 | $1,841,720 | $-1,274,280 | -40.89 % | $-257,187 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2008-05-14 | 2008-03-31 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 130,900 | No Change | 0 | 0 % | $1,685,992 | $1,470,007 | $-215,985 | -12.81 % | $0 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2008-02-14 | 2007-12-31 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 130,900 | No Change | 0 | 0 % | $1,954,337 | $1,470,007 | $-484,330 | -24.78 % | $0 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2007-11-14 | 2007-09-30 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 130,900 | No Change | 0 | 0 % | $2,104,872 | $1,470,007 | $-634,865 | -30.16 % | $0 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2007-08-10 | 2007-06-30 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 130,900 | Added More | 129,000 | 6789.47 % | $1,450,372 | $1,470,007 | $19,635 | 1.35 % | $19,350 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2007-05-15 | 2007-03-31 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 1,900 | No Change | 0 | 0 % | $18,240 | $21,337 | $3,097 | 16.97 % | $0 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2007-02-14 | 2006-12-31 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 1,900 | No Change | 0 | 0 % | $19,057 | $21,337 | $2,280 | 11.96 % | $0 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2006-11-14 | 2006-09-30 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 1,900 | No Change | 0 | 0 % | $21,508 | $21,337 | $-171 | -0.79 % | $0 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2006-08-14 | 2006-06-30 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 1,900 | No Change | 0 | 0 % | $11,723 | $21,337 | $9,614 | 82.00 % | $0 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2006-05-15 | 2006-03-31 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 1,900 | No Change | 0 | 0 % | $15,181 | $21,337 | $6,156 | 40.55 % | $0 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2006-02-14 | 2005-12-31 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 1,900 | No Change | 0 | 0 % | $13,794 | $21,337 | $7,543 | 54.68 % | $0 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2005-11-10 | 2005-09-30 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 1,900 | No Change | 0 | 0 % | $9,519 | $21,337 | $11,818 | 124.15 % | $0 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2005-08-08 | 2005-06-30 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 1,900 | No Change | 0 | 0 % | $10,279 | $21,337 | $11,058 | 107.57 % | $0 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2005-05-05 | 2005-03-31 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 1,900 | Sold Some | -122,700 | -98.47 % | $5,491 | $21,337 | $15,846 | 288.58 % | $-1,023,318 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2005-02-10 | 2004-12-31 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 124,600 | Sold Some | -6,900 | -5.24 % | $585,620 | $1,399,258 | $813,638 | 138.93 % | $-45,057 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2004-11-17 | 2004-09-30 | 13F-HR/A | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 131,500 | New Holding | 131,500 | 100 % | $568,080 | $1,476,745 | $908,665 | 159.95 % | $908,665 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2004-08-13 | 2004-06-30 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 0 | Sold All | -139,500 | -100 % | - | - | - | 146.27 % | $-930,465 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2004-05-12 | 2004-03-31 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 139,500 | Added More | 12,100 | 9.49 % | $997,425 | $1,566,585 | $569,160 | 57.06 % | $49,368 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2004-02-13 | 2003-12-31 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 127,400 | No Change | 0 | 0 % | $1,058,694 | $1,430,702 | $372,008 | 35.13 % | $0 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2003-11-14 | 2003-09-30 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 127,400 | No Change | 0 | 0 % | $714,714 | $1,430,702 | $715,988 | 100.17 % | $0 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2003-08-12 | 2003-06-30 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 127,400 | Sold Some | -10,000 | -7.27 % | $691,782 | $1,430,702 | $738,920 | 106.81 % | $-58,000 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2003-05-14 | 2003-03-31 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 137,400 | Added More | 1,700 | 1.25 % | $798,294 | $1,543,002 | $744,708 | 93.28 % | $9,214 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2003-02-11 | 2002-12-31 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 135,700 | Sold Some | -6,600 | -4.63 % | $663,573 | $1,523,911 | $860,338 | 129.65 % | $-41,844 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2002-11-14 | 2002-09-30 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 142,300 | Added More | 44,000 | 44.76 % | $1,408,770 | $1,598,029 | $189,259 | 13.43 % | $58,520 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2001-05-23 | 2001-03-31 | 13F-HR/A | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 98,300 | Added More | 30,400 | 44.77 % | $1,188,447 | $1,103,909 | $-84,538 | -7.11 % | $-26,144 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2000-05-12 | 2000-03-31 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 67,900 | Sold Some | -47,600 | -41.21 % | $700,049 | $762,517 | $62,468 | 8.92 % | $-43,792 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 2000-02-11 | 1999-12-31 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 115,500 | Added More | 77,500 | 203.94 % | $1,263,570 | $1,297,065 | $33,495 | 2.65 % | $22,475 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 1999-11-12 | 1999-09-30 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 38,000 | Added More | 8,000 | 26.66 % | $491,720 | $426,740 | $-64,980 | -13.21 % | $-13,680 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 1999-08-12 | 1999-06-30 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 30,000 | Added More | 15,000 | 100.00 % | $300,000 | $336,900 | $36,900 | 12.30 % | $18,450 | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
| 1999-05-14 | 1999-03-31 | 13F-HR | Isis Pharmaceuticals Inc | ISIS | US | Therapeutics | 15,000 | No Compare | - | - % | $160,350 | $168,450 | $8,100 | 5.05 % | | | | | | | History of Schwab Charles Investment Management Inc Ownership Of Isis Pharmaceuticals Inc |
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